Internal dosimetry for alpha emitters radiopharmaceuticals in biological tissue studied with the FLUKA code

M. VALENTE; F. MALANO; P. PÉREZ

Proceedings of Science

International School for Advanced Studies

Lugar: Trieste; Año: 2014

1824-8039

Nuclear medicine clinical practices for neoplasic disease diagnose and treatment are based on the incorporation of alpha, beta and gamma radiotracers and radiopharmaceuticals, which might be associated with potential damage. Thus, being necessary accurate dosimetry strategies. In vivo absorbed dose appears as an ideal solution. However, its implementation in clinics does not attain enough reliability. In this sense, different approaches were proposed for internal dosimetry calculations. This work presents a novel analytical-numerical approach for internal dosimetry purposes. Dedicated Monte Carlo simulations were performed by subroutines adapted from the FLUKA code. In-water EDK were evaluated at different photon energies and some typical gamma-emitters radiopharmaceuticals; whereas DPK were obtained for both alpha- and beta- emitters. Additionally, EDK and DPK were calculated for several biological tissues.