GENUINE ESSIAC (ESSIAC LATINOAMERICA): RA- DIOPROTECTIVE PROPERTIES OVER IONIZING RADI- ATION AND CHEMICAL SUBSTANCE PROMOTERS OF REACTIVE SPECIES PRODUCTION

MARTINEZ MARIGNAC VERONICA L; OERTLIN GLORIA; FAVANT JOSE LUIS

Mar Del Plata

Congreso; Reunión Anual SAIC, SAB AAFE AACYTAL 2023; 2023

SAIC, SAB AAFE AACYTAL

434. 181. GENUINE ESSIAC (ESSIAC LATINOAMERICA): RA-DIOPROTECTIVE PROPERTIES OVER IONIZING RADI-ATION AND CHEMICAL SUBSTANCE PROMOTERS OF REACTIVE SPECIES PRODUCTIONVeronica L. Martinez Marignac1, Gloria S. Oertlin1, Lucia Cer-vantes1,2, Leonel Mondragon1,3, Jose Luis Favant1,2.1 Laboratorio Interdisciplinario de Biologia y Genetica Mole-cular –IBIOGEM, CICYTTP (CONICET, Prov. ER y UADER). 2. Facultad de Ingeniería, UNER. 3 Facultad de Ciencias de la Salud, UAP.We demonstrated previously that ESSIAC tea, a freely available 8 herbs tea in the United States and Canada, has an antioxidant andrepairing action against radiation damage. ESSIAC tea has shown potent thus controverted antitumor activity, and its herbs ROS scav-enger feature.Here we intend to evaluate its capacity to prevent or repair damage produced by chemical ROS production substances, in this case by very low dose of chloroform, a model developed to study hepatic fibrosis.On a validated murine model, we performed acute exposure to 40mSv XRay and chloroform injection, we divid-ed randomly BALB/c male mice in 6 groups: controls, tea drinkers, irradiated, chloroform injected, tea plus irradiated and tea plus chlo-roform injected mice. XRay and chloroform were acute administered on week 11, while tea was administered ad libitum instead of water from week 6 and we perform sacrificed on week 11 (24 or 48h af-ter chemical or physical injures). ROS production was confirmed by alkaline comet assay (ACA) on peripheral blood after 24 and 48h; a significant comet % reduction on animals receiving ESSIAC plus chloroform or IR administration (pValue