INVESTIGADORES
MONGE Maria Eugenia
congresos y reuniones científicas
Título:
Metabolomic Investigation of Ovarian Cancer Progression in a High-grade Serous Ovarian Cancer DKO Mouse Model
Autor/es:
CHRISTINA MICHELE JONES; MARÍA EUGENIA MONGE; JAEYEON KIM; MARTIN M. MATZUK; JOHN F. MCDONALD; FACUNDO M. FERNÁNDEZ
Lugar:
Tsuruoka
Reunión:
Conferencia; 10th Annual International Conference of the Metabolomics Society; 2014
Institución organizadora:
Metabolomics Society
Resumen:
Ovarian cancer is the fifth deadliest cancer among women and the leading cause of death among gynecologic cancers. Asymptomatic early stages combined with a lack of high specificity biomarkers contribute to late diagnosis. A Dicer/Pten double knockout mouse model of high-grade serous ovarian cancer, the subtype causing 70% of ovarian cancer deaths, is here studied to better understand disease progression. Metabolic profiles of healthy (H) and early stage (ES) cancerous blood sera from Dicer-Pten DKO mice were acquired using UPLC-MS. With only eighteen features down-selected from these profiles, oPLS-DA models discriminated H from ES with 100% sensitivity and 100% specificity, respectively.
