Improving Diagnosis of Genitourinary Cancers: Biomarker Discovery Strategies through Mass Spectrometry-based Metabolomics

MANZI, MALENA; RIQUELME, GABRIEL; ZABALEGUI, NICOLÁS; MONGE, MARÍA EUGENIA

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ELSEVIER SCIENCE BV

Año: 2020 vol. 178

0731-7085

The genitourinary oncology field needs integration of results from basic science,epidemiological studies, clinical and translational research to improve the currentmethods for diagnosis. MS-based metabolomics can be transformative for diseasediagnosis and contribute to global health parity. Metabolite panels are promising totranslate metabolomic findings into the clinics, changing the current diagnosis paradigmbased on single biomarker analysis. This review article describes capabilities of the MSbasedoncometabolomics field for improving kidney, prostate, and bladder cancerdetection, early diagnosis, risk stratification, and outcome. Published works arecritically discussed based on the study design; type and number of samples analyzed;data quality assessment through quality assurance and quality control practices; dataanalysis workflows; confidence levels reported for identified metabolites; validationattempts; the overlap of discriminant metabolites for the different genitourinary cancers;and the translation capability of findings into clinical settings. Ongoing challenges arediscussed, and future directions are delineated.