CONICET | Buscador de Institutos y Recursos Humanos

The involvement of thyroid hormones in initiating andexacerbating cardiovascular disease has not been completelyelucidated; therefore, thyroid disorders could constitute a newvascular risk factor. Previous studies show an increase in theprevalence of thyroid disorders linked to heart disease, in bothpediatric and adult populations (Yamawaka et al., 2019).The fetal and neonatal period can be considered relevantstages of life in which hormonal, metabolic and neuronalalterations could modulate the expression of differentcardiac genes, important for the development of thecardiovascular system (Minerath et al., 2019, Forini et al.,2019).It is known that the thyroid gland regulates functions involved inmaintaining an adequate balance in the internal environment,and that it contributes to the bodys adaptation to the externalenvironment. For this reason, disorders that affect this glandhave a great impact on homeostasis. Thyroid hormones have asignificant impact on cardiac function, mediated by genomicand non-genomic effects, which correlate with the normaldevelopment and maturation of the cardiovascular systemduring the neonatal period (Kotsopoulou et al., 2022).Thyroid hormone is a critical regulator of growth and development, both in fetal and postnatal life.Congenital and postnatal hypothyroidism did not affect systolic and diastolic cardiac function differently.However, post-thyroid disorder affect differentially modulation of hemodynamic parameters taking into account the time ofonset of thyroid disorders.

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