The tyramine receptor TYRA-3 is involved in the neural coordination of oxidative stress response in the model organism C. elegans.

VEUTHEY TANIA V; DE ROSA MARIA JOSE; RAYES DIEGO

Congreso; XXX Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2015

The nervous system plays a pivotal role in the coordination of systemic stress response in multicellular organism. However, the molecular and cellular bases of this modulation are poorlyunderstood. Oxidative stress constitutes one of the most complex forms of systemic stress and plays a major role in the pathogenesis of conditions such as diabetes, cancer andneurodegenerative disorders. In addition, strong evidences have linked increased oxidative stress with aging. Our previous results have related the neural tyraminergic signaling, theinvertebrate counterpart for adrenergic transmission, and the systemic response to starvation and thermal stress in C. elegans. By analyzing the survival of different C. elegans mutant strains,here we evaluated the role of this aminergic signaling in the iron-induced oxidative stress response. Our results suggest that inhibition of tyramine release in the nervous system is essential formounting an appropriate systemic response to oxidative stress. Moreover we identified the GPCR TYRA-3 as the receptor involved in this neural modulation. We are now evaluating both, thespecific cells where TYRA-3 expression is required as well as the molecular pathways underlying this regulation. Our work will contribute to identify cellular and molecular mechanismsinvolved in neuronal coordination of systemic stress response, leading to a better understanding of the integration between stress sensory perception and the response in non-neuronal cells.