INVESTIGADORES
CHERTOFF Mariela Sandra Juana
artículos
Título:
Short and long-term analysis and comparison of neurodegeneration and inflammatory cell response in the ipsilateral and contralateral hemisphere of the neonatal mouse brain after hypoxia/ischemia
Autor/es:
SHRIVASTAVA KALPANA; CHERTOFF, MARIELA; LLOVERA GEMMA; RECASENS MIREIA; ACARIN LAIA
Revista:
Neurology Research International
Editorial:
Hindawi Publishing Corporation
Referencias:
Año: 2012 vol. 2012 p. 1 - 28
ISSN:
2090-1852
Resumen:
Understanding the evolution of neonatal hypoxic/ischemic is essential for novel neuroprotective approaches. We describe the
neuropathology and glial/inflammatory response, from 3 hours to 100 days, after carotid occlusion and hypoxia (8% O2, 55
minutes) to the C57/BL6 P7 mouse. Massive tissue injury and atrophy in the ipsilateral (IL) hippocampus, corpus callosum,
and caudate-putamen are consistently shown. Astrogliosis peaks at 14 days, but glial scar is still evident at day 100. Microgliosis
peaks at 3 - 7 days and decreases by day 14. Both glial responses start at 3 hours in the corpus callosum and hippocampal fissure,
to progressively cover the degenerating CA field. Neutrophils increase in the ventricles and hippocampal vasculature, showing
also parenchymal extravasation at 7 days. Remarkably, delayed milder atrophy is also seen in the contralateral (CL) hippocampus
and corpus callosum, areas showing astrogliosis and microgliosis during the first 72 hours. This detailed and long-term cellular
response characterization of the ipsilateral and contralateral hemisphere after H/I may help in the design of better therapeutic
strategies.