INVESTIGADORES
RAMALLO Virginia
artículos
Título:
Random inbreeding, isonymy, and population isolates in Argentina
Autor/es:
DIPIERRI, JE.; RODRIGUEZ-LARRALDE, A; BARRAI, I; LOPEZ CAMELO, J; GUTIERREZ REDOMERO, E; ALONSO RODRIGUEZ, C; RAMALLO V; BRONBERG, R; ALFARO EL.
Revista:
Journal of Community Genetics
Editorial:
Springer Link
Referencias:
Año: 2014 p. 1 - 8
ISSN:
1868-310X
Resumen:
Population isolates are an important tool in identifying and mapping genes of Mendelian diseases and complex traits. The geographical identification of isolates represents a priority from a genetic and health care standpoint. The purpose of this study is to analyze the spatial distribution of consanguinity by random isonymy (FST) in Argentina and its relationship with the isolates previously identified in the country. FST was estimated from the surname distribution of 22.6 million electors registered for the year 2001 in the 24 provinces, 5 geographical regions, and 510 departments of the country. Statistically significant spatial clustering of FST was determined using the SaTScan V5.1 software. FST exhibited a marked regional and departamental variation, showing the highest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymy followed the same distribution. Recognized Argentinean genetic isolates are mainly localized at the north of the country, in clusters of high inbreeding. Given the availability of listings of surnames in high-capacity storage devices for different countries, estimating FST from them can provide information on inbreeding for all levels of administrative subdivisions, to be used as a demographic variable for the identification of isolates within the country for public health purposes.