INVESTIGADORES
RAMALLO Virginia
artículos
Título:
Random inbreeding, isonymy, and population isolates in Argentina
Autor/es:
DIPIERRI, JE.; RODRIGUEZ-LARRALDE, A; BARRAI, I; LOPEZ CAMELO, J; GUTIERREZ REDOMERO, E; ALONSO RODRIGUEZ, C; RAMALLO V; BRONBERG, R; ALFARO EL.
Revista:
Journal of Community Genetics
Editorial:
Springer Link
Referencias:
Año: 2014 p. 1 - 8
ISSN:
1868-310X
Resumen:
Population isolates are an important tool in identifying
and mapping genes of Mendelian diseases and complex
traits. The geographical identification of isolates represents a
priority from a genetic and health care standpoint. The purpose
of this study is to analyze the spatial distribution of
consanguinity by random isonymy (FST) in Argentina and its
relationship with the isolates previously identified in the
country. FST was estimated from the surname distribution of
22.6 million electors registered for the year 2001 in the 24
provinces, 5 geographical regions, and 510 departments of the
country. Statistically significant spatial clustering of FST was
determined using the SaTScan V5.1 software. FST exhibited a
marked regional and departamental variation, showing the
highest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymy
followed the same distribution. Recognized Argentinean genetic
isolates are mainly localized at the north of the country,
in clusters of high inbreeding. Given the availability of listings
of surnames in high-capacity storage devices for different
countries, estimating FST from them can provide information
on inbreeding for all levels of administrative subdivisions, to
be used as a demographic variable for the identification of
isolates within the country for public health purposes.