INVESTIGADORES
RAMALLO Virginia
artículos
Título:
High twinning rate in Cândido Godói: a new role for p53 in human fertility
Autor/es:
TAGLIANI RIBEIRO, A; PASKULIN, DD; OLIVEIRA, M; ZAGONEL DE OLIVEIRA, M; LONGO, D; RAMALLO, V; ASHTON-PROLLA, P; SARAIVA-PEREIRA, ML; FAGUNDES, NJR; SCHULER-FACCINI, L; SILVEIRA MATTE, U
Revista:
HUMAN REPRODUCTION
Editorial:
OXFORD UNIV PRESS
Referencias:
Lugar: Oxford; Año: 2012 vol. 27 p. 2866 - 2871
ISSN:
0268-1161
Resumen:
BACKGROUND Cândido Godói (CG) is a small town in South Brazil, which has the highest prevalence of twin births in Brazil. Recently, a number of studies have shown that p53 plays an important role in reproduction through blastocyst implantation and intra utero embryo survival. Thus, gene polymorphisms in the p53 pathway were investigated in this population. METHODS Single nucleotide polymorphisms from five genes in the p53 pathway were investigated, as well as background characteristics of 42 mothers of twins (cases) and 101 mothers of singletons (controls), all residents from CG. RESULTS Mothers of twins have higher number of pregnancies and higher frequencies of P72 allele at TP53 and T allele at MDM4 genes compared with controls. Logistic regression shows that both TP53 and number of pregnancies maintained their association with twinning (P =0.004 and P =0.002, respectively), with TP53 having a higher odds ratio than number of pregnancies (2.73 versus 1.70, respectively). No interactive effect between TP53 and MDM4 (P =0.966) is observed. As expected, mothers of twins have three times more cases of cancer in their first-degree relatives than control mothers (P =0.011). CONCLUSIONS Our results suggest that the P72 allele of TP53 is a strong risk factor for twinning in CG, while the number of pregnancies and the T allele at MDM4 may represent weaker risk factors. These two alleles are associated with infertility, but the anti-apoptotic effect of low levels of p53 in general, and of the P72 allele in particular, may play a role after implantation, enhancing the chance for a double pregnancy to succeed to term.