INVESTIGADORES
MANES Facundo Francisco
congresos y reuniones científicas
Título:
Extrapyramidal Symptoms In Frontotemporal Dementia
Autor/es:
ANABEL CHADE; TERESA TORRALVA; MARÍA ROCA; EZEQUIEL GLEICHGERRCHT; FACUNDO MANES
Lugar:
Honolulu
Reunión:
Encuentro; 63rd AAN 2011 Annual Meeting; 2011
Institución organizadora:
American Academy of Neurology
Resumen:
OBJECTIVE: To evaluate the prevalence of parkinsonism in patients with behavioral variant frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA). BACKGROUND: FTD is pathologically heterogeneous. The prevalence of extrapyramidal signs in patients with bvFTD and PPA has not yet been systematically studied. DESIGN/METHODS: We enrolled patients fulfilling diagnosis of FTD. Patients with parkinsonian symptoms were diagnosed according to United Kingdom Parkinson's Disease Society Brain Bank criteria. The study participants were assessed with the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS) to quantify their motor status and with the Hoehn and Yahr rating scale for severity of motor signs. The results were compared with those of patients with temporal variant of FTD using U Mann Whitney's test for between-group comparison on each item of the UPDRS. RESULTS: A total of 23 patients with bvFTD and 9 PPA were compared. Mean age was 69.84, SD 8.65, range 49 to 84, 62.5 % were men. A total of 78.26 % with bvFTD presented parkinsonism and 55.5 % of PPA. The mean total UPDRS score for bvFTD was 17.35 SD 12.74 (range 0 to 37) vs PPA 10.72 SD 15.67 (range 0 to 51).The Hoehn & Yahr scale for bvFTD was 2.13 SD 0.92 (range 0 to 4) and for PPA was 1.72 SD 0.75 (range 0 to 3). Tremor when present was postural or action type. Left side predominance was 44 % and left side was 22 % of all FTD cases. The two groups differed significantly for speech (p = 0.018), facial expression (p = 0.045), left arm postural tremor (p = 0.035), left arm rigidity (p = 0.031). CONCLUSIONS: Rigidity, bradykinesia, postural tremor were the most typical findings more severe in bvFTD than in PPA. Detecting parkisonism in patients with FTD is crucial for good clinical practice given potential therapeutic possibilities targeting Tau.
