INVESTIGADORES
MANES Facundo Francisco
congresos y reuniones científicas
Título:
Extrapyramidal symptoms in frontotemporal dementia
Autor/es:
ANABEL CHADE; MARÍA ROCA; EZEQUIEL GLEICHGERRCHT; TERESA TORRALVA; FACUNDO MANES
Lugar:
Buenos Aires
Reunión:
Congreso; 14th International Congress of Parkinson´s Disease and Movement Disorders; 2010
Institución organizadora:
The Movement Disorder Society
Resumen:
Background: FTD is pathologically heterogeneous. The prevalence of extrapyramidal signs in patients with behavioural variant FTD (bvFTD) and primary progressive aphasia (PPA) has not yet been sysmtematically studied. Methods: The objective was to evaluate the prevalence of parkinsonism in patients with bvFTD and PPA fulfilling diagnosis of FTD, Parkinsonian symptoms were diagnosed according to the diagnostic criteria of the United Kingdom Parkinsons Disease Society Brain Bank. The study participants were assessed with the motor part of the Unified Parkionson´s Disease Rating Scale (UPDRS) to quantify their motor status and with the Hoehn and Yahr rating scale for severity of motor signs. The results were compared with those of patients with PPA using U Mann-Whitneys test for between-group comparison on each item of the UPDRS. Results: A total of 23 patients with bvFTD and 9 PPA were compared. Mean age was 69.84, SD 8.65, range 49 to 84, 62.5% were men. A total of 78.26% with bvFTD presented parkinsonism and 55.5% of PPA. The mean total UPDRS score for bvFTD was 17.35 SD 12.74 (range 0 to 37) vs PPA 10.72 SD 15.67 (range 0 to 51). The Hoehn & Yahr scale for bvFTD was 2.13 SD 0.92 (range 0 to 4) and for PPA was 1.72 SD 0.75 (range 0 to 3). Tremor when present was postural or action type. Left side predominance was 44% and left side was 22% of all FTD cases. The two groups differed significantly for speech (p=0.018), facial expression (p=0.045), left arm postural tremor (p=0.035), left arm rigidity (p=0.031). Conclusions: Rigidity, bradykinesia, postural tremor were the most typical findings more severe in bvFTD than in PPA. Detecting parkinsonism in patients with FTD is crucial for good clinical practice given potential therapeutic possibilities targeting tau.
