Cognitive impairment in patients with early stages of relapsing-remitting multiple sclerosis correlates with structural changes in fronto-subcortical fiber tracts

MARÍA ROCA; FRANCISCO MELI; MARCELA FIOL; MARÍA DE LUJÁN CALCAGNO; SILVINA CARPINTIERO; GABRIELA DE PINO; F VENTRICE; MARTÍN MIGUEL; LUCIANA VITA; FACUNDO MANES; JORGE CORREALE

Thessaloniki

Congreso; 21st Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 10th Annual Meeting of the Committee for treatment and Research in Multiple sclerosis; 2005

European Committee for Treatment and Research in Multiple Sclerosis, Committee for treatment and Research in Multiple sclerosis

Objectives: 1) To detect specific executive deficits in patients at an early stage of relapsing-remitting Multiple Sclerosis (RRMS), 2) To explore the degree of correlation between sequence magnitude derived from fronto-subcortical Diffusion Tensor MR imaging (DT-MRI) and measures of cognitive impairment. Material and Methods: Twelve patients with diagnosis of RRMS according to Poser’s criteria, with mild clinical disability (EDSS