EFffects of soy milk on brain aging

ALBARRACÍN AL; PRCHAL A; PINTOS S; ORQUEDA D; BENVENUTO S; FUENTES L; PALLADINI L; FAJRE L; SCACCHI F; SOSA ML; FONTENLA DE PETRINO S

TUCUMAN

Jornada; XXIV Jornadas Cientificas de la Asociación de Biología de Tucumán; 2007

We studied the antioxidative effecrs of´ soy milk as a complemeny standard feeding on age related structural changes and neurona! nitric oxide expression ancl activity. Male Wistar rats were ran­domly assigned to two diets from weaning: A) balanced food and water (control, N=6); B) balanced food and soymilk (experimen­tal, N=6). Ar 3 and 15 months animals were intracardially perfused under general anaesthesia and prepared for routine histological analysis of histochemical analysis (NADPH diaphorase). Basal counts ofhippocall1pal neurons at 3 1110nths were 80.27± 3.7 neural field 40x. Fifteen month old experimental rats showed diminished rates of hippocampal neuronal loss (67.78± 3.1 neur/field 40x) as compared to controls (57.94±2.9 neur/field 40x). The NADPH diaphorase reactive cell distribution pattern was similar at 3 and 15 months. However, the number of NADPH diaphorase reactive cells was significantly lower in experimental animals (ANOVA, p