The concept of electroporation energy in electorporation-based models

OLAIZ, N; TURJANSKI, P; MARINO, M.; LUJAN, E; MÁRQUEZ, A; MINOTTI, F; ZUCCO, E; TELLADO, M; GARABALINO, MA; MICHINSKI, S; MAGLIETTI, F; SANTA CRUZ, G; MARSHALL, G

Norflok

Congreso; 2nd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies; 2017

International Society for Electroporation-Based Technologies and Treatments (ISEBTT)

Electroporation (EP) based theoretical models have been discussed since long. In particular, those based on the solution of the nonlinear Laplace equation using a variable electric conductivity coefficient expressed as a function of electric field, temperature and other variables, had been widely used. We introduce the concept of electroporation energy and its use in the solution of the nonlinear Laplace equation in which the tissue electric conductivity is made dependent of the electric field, temperature, and permeabilization. The permeabilization function links the tissue and membrane multi-scale level through the electroporation energy (energy absorbed by the membrane to change its state). The total electric energy pumped into the system is mainly converted into electroporation, thermal and mechanical energies.