INVESTIGADORES
ADUR Javier Fernando
artículos
Título:
Endothelin system in intestinal villi: A possible role of endothelin-2/vasoactive intestinal contractor in the maintenance of intestinal architecture
Autor/es:
BIANCHI M; ADUR J; TAKIZAWA S; SAIDA K; CASCO VH
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2012 p. 1113 - 1118
ISSN:
0006-291X
Resumen:
The endothelin system consists of three ligands (ET-1, ET-2 and ET-3) and at least two receptors (ETA and
ETB). In mice ET-2 counterpart is a peptide originally called ??vasoactive intestinal contractor?? (VIC) for
this reason, this peptide is frequently named ET-2/VIC. In intestinal villi, fibroblasts-like cells express
endothelin?s receptors and response to ET-1 and ET-3 peptides, changing their cellular shape. Several
functions have been attributed to these peptides in the ??architecture?? maintenance of intestinal villi acting
over sub-epithelial fibroblasts. Despite this, ET-2/VIC has not been analyzed in depth. In this work we
show the intestine gene expression and immunolocalization of ET-1, ET-2 and the ETA and ETB receptors
from duodenum to rectus and in the villus?crypt axis in mice, allowing a complete analysis of their functions.
While ET-1 is expressed uniformly, ET-2 had a particular distribution, being higher at the bottom of
the villi of duodenum, ileum and jejunum and reverting this pattern in the crypts of colon and rectus,
where the higher expression was at the top. We postulated that ET-2 would act in a cooperative manner
with ET-1, giving to the villus the straight enough to withstand mechanical stress.