Cephalotin Penetration into Muscle Tissue Fluid and Muscle Tissue

ROBERTO RULE; MARIANGELES VITA; JOSEFINA LACUNZA

Latin American Journal of Pharmacy

Acta Farmacéutica Bonaerense

Año: 2008 vol. 27

2362-3853

SUMMARY. The aim ot fhe present work was to compare the penetration in muscle tissue fluid (MTF)and muscle tissue (MT) of cephalotin administered in rabbits. Animals were distributed in Trial 1 (n = 15)and Trial 2 ( n= 6). In the Trial 1 the animals were implanted in ischiotibial muscle with non reactive materialcages. Animals recibed subcutaneously (sc) cephalotin (20 mg/kg) and blood, MTF and MT sampleswere recollected. In the Trial 2 the animals recibed cephalotin (20 mg/kg) intravenously (iv) and bloodsamples were recollected. Pharmacokinetic analysis were performed using a non-compartmental model.Results: terminal disposition rate constant (λz) (serum iv) 1.43 ± 0.54, (serum sc) 1.90, (MTF) 0.57 and(MT) 1.80 h?1; elimination half-life (t1/2) (serum iv) 0.53 ± 0.13, (serum sc) 0.36, (MTF) 1.20 and (MT) 0.38h; the area under the curve [AUC(0-6)] (serum iv) 60.40 ± 38.20, (serum sc) 45.90, (MTF) 21.60 and (MT)3.00 μg.ml?1.h. and the bioavailability (F) was 76%. The penetration of cephalotin in MTF and MT were47.70 and 6.43%, respectively. Cephalotin administered subcutaneously in rabbit presented higherbioavailability, distribution in extracelullar fluid and low penetration in muscle tissue.