Membranes applied to guided bone tissue regeneration: Use of hydroxyapatite nanoparticles to improve their biological properties

D'ELÍA NOELIA LAURA; RIAL SILVA, RAMON; SARTUQUI JAVIER; ÉRCOLI, DANIEL; RUSO JUAN MANUEL; MESSINA PAULA VERÓNICA; MESTRES, GEMMA

Conferencia; Reunión Virtual Anual NANOMED-ar ?1st zooming into preclinical nanomedicines in the era of Covid 19?; 2020

Guided bone tissue regeneration is widely employed, especially in the oralmaxillofacial region. The main objectives of the application of a barrier membrane are: (a) covering a bone defect supporting the ingrowth of osteogenic cells without competition from other cells, and (b) preventing micromovement of the bone graft[1]. In recent years, various membranes applied for guided bone regeneration have been developed. Among them, biodegradable membranes have the advantage to avoid a second surgical procedure to extract them and bioactive membranes ensure tight bonding of the biomaterial within the host tissue. Our research group developed a biodegradable material composed of alginate crosslinked with hydroxyapatite nanoparticles[2]. Alginate is widely used in biomedicalapplications due to its clinically proved biocompatibility, while hydroxyapatitenanoparticles stimulate osteoblast differentiation and coagulation process [3?5].This time, the objective of our research was to develop a bifunctional bilayermembrane capable of allowing healing on one of its faces and, stimulating bonetissue regeneration on the other. This membrane, rather than merely acting as apassive barrier, it has potential osteoinductive properties [6].