Novel sodium alginate ? hydroxyapatite nanoparticles bilayer membranes: synthesis and characterization

D'ELÍA NOELIA LAURA; RIAL SILVA, RAMON; SARTUQUI JAVIER; ÉRCOLI, DANIEL; RUSO JUAN MANUEL; MESSINA PAULA VERÓNICA; MESTRES, GEMMA

Conferencia; The Scandinavian Society for Biomaterials 13th annual meeting in 2020.; 2021

Guided bone regeneration consists in covering a bone defect with a membrane that acts as a barrier (from rapidly growing epithelium) in order to support both the growth of osteoblasts and wound healing1. Alginate (ALG) is widely used in biomedical applications due to its clinical biocompatibility, and hydroxyapatite nanoparticles (HAn) stimulate osteoblast differentiation3. The main goal of this work was to develop a novel ALG-HAn bifunctional membrane capable of stimulating bone formation on one side and wound healing on the other.