Exercise Ameliorates Endocrine Pancreas Damage Induced by Chronic Cola Drinking in Rats

OTERO-LOSADA M, GONZÁLEZ J, MÜLLER A, OTTAVIANO G, CAO G, AZZATO F, AMBROSIO G, MILEI J

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2016 vol. 11 p. 1 - 13

1932-6203

PURPOSE:This study evaluates whether the daily practice of an exercise routine might protect from endocrine pancreas damage in cola drinking rats.METHODS:Forty-eight Wistar rats were randomly assigned to 4 groups depending on a) beverage consumption ad libitum, water (W) or cola beverage (C), and b) physical activity, sedentary (S) or treadmill running (R). Accordingly, 4 groups were studied: WS (water sedentary), WR (water runner), CS (cola sedentary) and CR (cola runner). Body weight, nutritional data, plasma levels of glucose, creatinine, total cholesterol and cholesterol fractions, and triglycerides (enzymocolorimetry), and systolic blood pressure (plethysmography) were measured. After 6 months, euthanasia was performed (overdose sodium thiopental). Pancreatic tissue was immediately excised and conventionally processed for morphometrical and immunohistochemical determinations.RESULTS:The effects of running and chronic cola drinking on pancreas morphology showed interaction (p