INVESTIGADORES
ANDREOLI Maria Florencia
artículos
Título:
Refeeding with conjugated linoleic acid increases serum cholesterol and modifies serum, liver and adipose tissue fatty acid profile after 48 hours of fasting in rats
Autor/es:
CASTRO, GABRIELA; ANDREOLI, M. FLORENCIA; ILLESCA, P; OVIDIO, P; BERNAL, CLAUDIO; ALCEU, J; VANNUCCHI, H
Revista:
NUTRICIóN HOSPITALARIA
Editorial:
AULA MEDICA EDICIONES
Referencias:
Lugar: Madrid; Año: 2014 vol. 30 p. 1303 - 1312
ISSN:
0212-1611
Resumen:
There is no consensus about the effects of conjugated
linoleic acid (CLA) on lipid metabolism, especially in animals
fed a high-fat diet. Therefore, the objective of the
present study was to evaluate the incorporation of CLA
isomers into serum, liver and adipose tissue, as well as the
oxidative stress generated in rats refed with high-fat diets
after a 48 hour fast. Rats were refed with diets containing
soybean oil, rich in linoleic acid [7% (Control Group - C)
or 20% (LA Group)], CLA [CLA Group ? 20% CLA mixture
(39.32 mole% c9,t11-CLA and 40.59 mole% t10,c12-
CLA)], soybean oil + CLA (LA+CLA Group - 15.4% soybean
oil and 4.6% CLA) or animal fat (AF, 20% lard).
The CLA group showed lower weight gain and liver weight
after refeeding, as well as increased serum cholesterol.
The high dietary fat intake induced fat accumulation
and an increase in α-tocopherol in the liver, which were
not observed in the CLA group. Circulating α-tocopherol
was increased in the CLA and CLA+LA groups. The high-
fat diets reduced liver catalase activity. CLA isomers
were incorporated into serum and tissues. In this shortterm
refeeding experimental model, CLA prevented hepatic
fat accumulation, although it produced an increase
in serum cholesterol.