MDD and BPD: Child maltreatment, stress, cortical thickness and volume.

VICENTE CAMACHO-TÉLLEZ; MS LADRÓN DE GUEVARA; WAINSZTEIN AE; X. GOLDBERG; CASTRO MN; B.M. DUARTE ABRITTA; C. SORIANO-MAS; N. CARDONER; C. NEMEROFF; VILLARREAL MF; GUINJOAN, S.M.

LISBOA

Congreso; Congreso Internacional de Psiquiatría WPA; 2019

ASOCIACION DE PSIQUIATRAS MUNDIAL

Background and objective. Adverse experiences in childhood have been related to structural and functional changes in the brain and in the neurobiological systems of stress; there is an association between suffering such experiences and developing mental illnesses in adulthood such as Major Depressive Disorder (MDD) or Borderline Personality Disorder (BPD). Both disorders share clinical and biological characteristics, such as those related to the neural circuit that regulates emotions; however, there is no consensus regarding whether they are two different manifestations of the same disease, or they are two independent entities. The objective is to describe the differences in cortical thickness, brain volumetry, the history of adverse childhood experiences between both disorders and explore the correlation between these experiences and cortical thickness. Methods: Adverse Childhood Experiences (ACE) refer to some of the most intense and frequent sources of stress that children may suffer at an early age; include multiple types of abuse, negligence, violence between parents or caregivers, other types of serious domestic dysfunction, such as alcohol and substance abuse, and peer violence or violence in their community. Magnetic Resonance Images, High Resolution MRI T1 contrast by FreeSurfer version 6.0 for Subcortical volumetry and cortical thickness. Conclusions. The ACE-IQ score suggest the influence of ACE on the development of both disorders.The globus pallidum volume could be an indicator that differentiates both disorders. MDD patients have smaller cortical thickness. ACE could influence anatomical changes.