Protective effects of Yerba mate (IIex paraguariensis) on prostate cancer development

SANTIANO, F.E.; FERNANDEZ M.A; ESPINO M.; ZYLA, L.E.; REY L; GOMEZ S; BRUNA, F.A.; PISTONE CREYDT, V.; PIETROBON E; ELIZALDE RAFAEL; SILVA MARIA; CARON R.; LÓPEZ-FONTANA, C.M.

NUTRITION

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2023 vol. 108 p. 1 - 8

0899-9007

Prostate cancer (PCa) is the most common adenocarcinoma in men >50 y of age. It has a longlatency period, which provides time for preventive strategies like incorporating healthy eating habits. Yerbamate (YM) intake has been associated with numerous health benefits. Since YM is one of the most popularinfusions in Argentina, the of this study was to examine the influence of YM on PCa development.Methods: We carried out an in vivo model of PCa through subcutaneous inoculation of transgenic adenocarcinomaof the mouse prostate-C1 cells in C57BL/6 mice. Subsequently, the animals were divided into twogroups: mate (25 mg/mL of YM in drinking water, n = 15), and control (only drinking water, n = 15). We alsodeveloped an in vitro model to study the direct effects of YM on three human PCa cell lines: lymph node carcinomaof the prostate (LNCaP), PC-3, and DU-145.Results: Our in vivo model showed that YM intake slightly reduced body weight, increased the latency oftumor appearance (P