Thioredoxin overexpression shows a cardioprotection against the redox metabolisms alterations initiated by air pollution exposure

MAGNANI N; GARCES M; PEREZ MV; MARCHINI T; CALABRÓ V; MARGIOTTIELLO N; CACERES L; ALVAREZ S; GELPI RJ; D' ANNUNZIO V; EVELSON P

Encuentro; LXV Annual meeting of argentine society of clinical investigation; 2020

Epidemiological studies showed correlations between daily changesin particulate matter (PM) concentration with cardiovascular diseasessuch as heart failure. PM-initiated reactive O2 species leading148 MEDICINA - Volumen 80 - (Supl. V), 2020to oxidative damage initiates adverse mechanisms. Thioredoxin-1(Trx1) through redox homeostasis regulation have shown an ischemia/reperfusion injury cadioprotection, reducing the infarct size.Therefore, the aim of the present project was to further assess theTrx1 protection against the cardiopulmonary toxicity initiated byResidual Oil Fly Ashes (ROFA) exposure, used as a PM inhalationmodel. Wild type (WT) and overexpressing Trx-1 (TRX) transgenicmice were intranasally instilled with a ROFA suspension (1 mg/kg) or saline. Heart tissue redox metabolism and cardiac functionwere evaluated 3h after treatment. Trx-1 overexpression was ableto revert the tissue O2 consumption decreased observed after ROFAexposure (p