“Thymic exportation and effector function of memory-like cd8+ t cells”

MARÍA ESTEFANÍA VIANO, ; ELIANA BAIGORRÍ,; CINTHIA STEMPIN, ; ANA ROSA PEREZ, ; BRENDA DI NATALE,; FLORENCIA PACINI, ; CAMILA BULFONI, ; FLORENCIA GONZÁLEZ; NICOLAS L. LIDÓN, ; FABIO CERBAN ; MARÍA CECILIA RODRÍGUEZ GALÁN

Congreso; Reunión anual de Sociedades de Biociencias SAI, SAIC Y SAFIS 2022.; 2022

Memory-like cells are a subset of CD8+ T cells that present a memoryphenotype without previous antigen encounter. They are a heterogeneousgroup of cells compose of innate CD8+ T cells that arisein the thymus (TIM) and are exported to secondary lymphoid organs(SLO) or, could develop directly in SLO where are named as virtualCD8+ T cells (TVM). TVM/TIM rapidly respond to IL-12 and IL-18 andplay a protective role during the early phase of bacteria, viral andparasite infections. We have previously reported that thymi from Trypanosomacruzi (Tc)-infected mice are highly enriched on TIM. TVM/TIM can be distinguished from conventional memory T cells (TMEM)by their low expression of CD49d. While residing in the thymus,phenotypic analysis in OT-I mice demonstrate that OVA tetramer+(OVAt+) single positive CD8 (SP8) cells (not specific for the parasite)expressed higher levels of CD44, CD122, CD5, CD69, Qa2 and decreasedlevels of CD24 compared to conventional polyclonal SP8cells (p