Expanded nanofibrous polymeric dressings containing tetracycline-loaded nanoparticles for wound healing

CARLOS BUSATTO; SILVESTRE BONGIOVANNI; FEDERICO FOOKES; DIANA ESTENOZ; GUSTAVO ABRAHAM

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials; 2023

INTEMA (UNMdP-CONICET)

This study aims to investigate novel nanofibrous polymeric dressings with an expanded structure, combined with mesoporous silica nanoparticles (MSN) as carriers of tetracycline, for potential application in skin tissue engineering. MSN were synthesized by the sol-gel process. The morphology, particle size and the specific surface area of MSN were characterized by SEM, TEM and BET analysis. Tetracycline was loaded into MSN via immersion of MSN in a concentrated drug solution, and the drug content was determined by TGA analysis and UV-Vis spectroscopy. The electrospinning parameters for PVA solutions were optimized, and different concentrations of MSN were incorporated. The resulting electrospun matrices were subjected to an expansion procedure in an ethanol solution of NaBH4. The physicochemical, superficial, thermal and morphological properties of the nanocomposite materials were characterized.