INVESTIGADORES
BUSATTO Carlos Alberto
congresos y reuniones científicas
Título:
Fabrication and evaluation of the mechanical behavior of electrospun matrices for the regeneration of urethra segments
Autor/es:
CARLOS BUSATTO; FLORENCIA MONTINI BALLARIN; ANDREÍNA TESIS; RICARDO ARMENTANO; DIANA ESTENOZ; GUSTAVO ABRAHAM
Lugar:
Foz do Iguaçu
Reunión:
Congreso; XX B-MRS Meeting; 2022
Institución organizadora:
Brazilian Materials Research Society (B-MRS)
Resumen:
Hypospadias and urethral stricture are the most common urethral abnormalities. The standard clinical treatment involves the transplantation of non-urological native tissues (gastrointestinal segments, oral mucosa, penis skin flap, and others). However, there is a limitation in the availability of autologous tissues and the risk of various complications. In this work, the fabrication of biomimetic urethral scaffolds based on poly(ε-caprolactone) (PCL) and hyaluronic acid (AH) has been explored for urethral reconstruction. The use of natural and synthetic polymers combines the highly favourable biological characteristics of natural polymers (hydrophilicity, biocompatibility and bioactive properties) and the mechanical behavior of synthetic polymers. The tubular scaffolds consisted of PCL nanofibers, co-electrospun fibers of PCL and AH, and PCL scaffolds infiltrated with AH. The materials were characterized by SEM and FT-IR, and the mechanical properties were evaluated using a continuous circulation biodynamic simulator (Bose® Corporation ElectroForce Systems Group). The urethral grafts were subjected to sinusoidal variations of internal pressure, consistent with normal physiological bladder pressure ranges and evaluated their compliance and mechanical response in vitro.