Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer’s Disease

ABULAFIA, CAROLINA; LOEWENSTEIN, DAVID; CURIEL-CID, ROSIE; DUARTE-ABRITTA, BÁRBARA; SÁNCHEZ, STELLA M.; VIGO, DANIEL E.; CASTRO, MARIANA N.; DRUCAROFF, LUCAS J.; VÁZQUEZ, SILVIA; SEVLEVER, GUSTAVO; NEMEROFF, CHARLES B.; GUINJOAN, SALVADOR M.; VILLARREAL, MIRTA F.

J. NEUROPSYCHIATRY CLIN. NEUROSCI.

American Psychiatric Press

Lugar: Washington, DC; Año: 2019 vol. 31 p. 25 - 36

0895-0172

Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer´s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer´s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer´s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer´s-relevant brain regions even at a relatively young age.