ADRENOCORTICAL INSUFFICIENCY DUE TO A SUSTAINED INCREASE IN THE AVAILABILITY OF SUCROSE IN THE DIET

CAROLINA VERÓNICA VECINO; JUAN SALVADOR CALANNI ; MORENA WISZNIEWSKI; SILVIA SANCHEZ PUCH; ESTEBAN MARTÍN REPETTO; CORA BEATRIZ CYMERYNG

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

Obesity and insulin-resistance (IR) have been linked to an increaseconsumption of sweet beverages. Higher glucocorticoid levels couldworsen this condition. In this study we evaluate long term effects ofthe administration of a sucrose-rich diet (SRD) on the morphologyand function of the adrenal gland and assessed the therapeuticeffect of hemin treatment. Rats were randomized into 4 groups(n=4): Control, SRD-fed rats (C, SRD) and C and SRD-fed ratsreceiving 15 mg/kg hemin (ip) (H and SRD+H) during the last twoweeks of the experimental period (12 weeks). Statistical significancewas analyzed by ANOVA followed by Tukey?s post hoc test.At the end of the experiment, serum metabolites such asglucose and total cholesterol levels (vs. C, p