Diet as confounding factor in the toxicity of the insecticide endosulfan in the freshwater fish Australoheros facetus.

CRUPKIN ANDREA CARINA; ITURBURU FERNANDO GASTÓN; CHISARI ANDREA; MENONE MIRTA LUJÁN

Porland

Congreso; SETAC North America 2010 Annual Meeting.; 2010

Society of Environmental Toxicology and Chemistry

A limitation of most of the biological effect measurements is that biomarker data interpretation must always be carefully controlled for false-negative and false-positive results, since the effects of non-pollution related confounding factors may interfere with biomarker responses. The goal of this work was to evaluate the effect of diet -if any- on the following biomarkers: glutathione-S-transferases (GST), glutathione reductase (GR), catalase (CAT) and malondialdehide (MDA) in liver of Australoheros facetus exposed to the insecticide endosulfan. Fishes were acclimated during 20 days with isocaloric diets containing 50 and 10% protein, diet 1 and 2 respectively. They were exposed to: 0 (control), 0.5 and 10 ug/L endosulfan during 24 h. Factorial ANOVA (factors: diet and treatment) with interaction and principal effects models was used. In controls the activity of GST and CAT was significantly lower (p