Electrostatic Interactions between ACBP and membrane. Proposal based on crystallographic data.

DIEGO F. VALLEJO; FERNANDO ZAMARREÑO; NATALIA PASQUALINI; AGUSTÍN PICCO; DIEGO M.A. GUÉRIN; J. RAUL GRIGERA; MARCELO D. COSTABEL

Bahía Blanca

Congreso; IV Reunión de la Asociación Argentina de Cristalografía.; 2008

Asociación Argentina de Cristalografía

The adsorption of macromolecules onto different kinds of surfaces is an area of experimental and theoretical interest due to different biotechnological and medical applications in which these macromolecules are involved. Despite the wealth of studies done in this field, the mechanism of protein-membrane interactions still constitutes an important research area with a myriad of different situations and biological problems still unsolved. To elucidate the mechanism of the interaction and determinate the importance of the non-specific electrostatic free energy in the interaction betwen ACBP and neutral or anionic membranes, we solved the crystallographic structure of armadillo Harderian gland ACBP and modeled computationally the interaction the ACBP with electrostatically differents membranes.