INVESTIGADORES
BUTASSI Estefania
artículos
Título:
Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
Autor/es:
CAMPOS, ADRIANA; RODRIGUES SOUZA, GREICE; DELLE MONACHE, FRANCO; BUTASSI, ESTEFANÍA; ZACCHINO, SUSANA; CECHINELO FILHO, VALDIR
Revista:
NATURAL PRODUCT COMMUNICATIONS
Editorial:
NATURAL PRODUCTS INC
Referencias:
Lugar: Westerville, Ohio; Año: 2015 vol. 10 p. 1589 - 1592
ISSN:
1934-578X
Resumen:
Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine andeleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeastsCandida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines ofCLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC valuesbetween 7.8 and 250 μg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential,contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections.
