Thyroid hormones influence metastatic and non-metastatic melanoma progression

CAYROL FLORENCIA; STERLE HA; MERCEDES DEBERNARDI; GONZALEZ G; CREMASCHI GA

Congreso; Reunión de Sociedades de Biociencias 2022; 2022

Thyroid hormones (THs) can affect tumor behavior by direct actions on cancer cells through molecular pathways involved in tumorigenesis, cancer metabolism, tumor proliferation/survival, invasiveness, and angiogenesis. To evaluate if THs can influence melanoma (ME) cells we first evaluated nuclear (TR) and membrane (integrin αVβ3) THs receptor levels in human (A375 and WM35) and mouse (B16F10 and B16F1) ME cells. We found transcriptional and protein levels of these receptors in all the ME cells analyzed. We also evaluated THs effect on ME cell proliferation and found that physiological and supraphysiological levels of these hormones induce 15 to 40% ME cell proliferation (p