Expression of matrix metalloproteinase 2 (MMP2) in the ovary in a Bovine stress model.

BELOTTI, M.; STASSI, A F; VELAZQUÉZ M.M.L.; MATILLER V.; ORTEGA H. H.; SALVETTI N.R.; PERREN, H

Mar del Plata

Congreso; LXI Reunión Científica anual de la Sociedad Argentina de Investigación Clínica(SAIC)-LXIV Reunión Anual de la Sociedad Argentina de Inmunología (SAI). XLVIII Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE). Reunión Asociación; 2016

Sociedad Argentina de Investigación Clínica (SAIC).

Dairy cattle are daily subjected to stressful situations some ofwhich can be associated to reproductive problems. Under theseconditions, the microenvironment of the ovary is modified, affectingdirectly normal follicular remodeling, necessary to ovulation. Theaim of this study was to evaluate the matrix metalloproteinase 2expression, enzyme that is involved in follicular wall tissue remodelingduring ovulation process. MMP2 expression was evaluatedby immunohistochemistry on ovarian samples of cows treated withadreconcorticotropin (ACTH) every 12 hours, for four days beforeovulation time. Primary, small preantral, large preantral, antral,atresic and preovulatory follicles of treated animals (n=5) andcontrol group (n=4) were evaluated. We detected that granulosacells of preovulatory follicles of ACTH treated group presentedhigher expression than those of antral follicles of control group(p