Altered Expression of Anti-Müllerian Hormone during the Early Stage of Bovine Persistent Ovarian Follicles.
DÍAZ P.U.; REY F.; GAREIS, N.; NOTARO, U.; MATILLER V; BELOTTI, M.; STASSI, A F; SALVETTI N.R.; ORTEGA H. H.
JOURNAL OF COMPARATIVE PATHOLOGY
ELSEVIER SCI LTD
Lugar: Amsterdam; Año: 2017
Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein expressed exclusively in thegonads. This hormone is an important regulator of the early growth of follicles throughinhibitory effects on the recruitment of primordial follicles into the pool of growing folliclesand on granulosa cell proliferation. Cystic ovarian disease (COD) is an important disorderaffecting the fertility of dairy cattle. In the present study, we evaluated the expression ofAMH in granulosa cells and AMH secretion into follicular fluid, in pre-ovulatory folliclesfrom control cows, animals with spontaneously arising COD and during the development ofthe disease, at 5, 10 and 15 days of follicular persistence. To this end, after an oestroussynchronization protocol, low doses of progesterone was administered for 5, 10 and 15 daysafter the expected day of ovulation (day 0 of follicular persistence) in treated cows (groupsP5, P10 and P15, respectively), using an intravaginal progesterone-releasing device. Resultsshowed a decrease in the expression of AMH in granulosa cells throughout folliculogenesis(P