PERSONAL DE APOYO
CASAL Juan Jose
artículos
Título:
Design, synthesis, and antitumor activity of new bis-aminomethylnaphthalenes
Autor/es:
MARIELA BOLLINI; JUAN JOSÉ CASAL; ANA MARÍA BRUNO
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2008 vol. 16 p. 8003 - 8010
ISSN:
0968-0896
Resumen:
A new series of bis-aminomethylnaphthalenes were synthesized in satisfactory overall yield, through a simple synthetic strategy using reductive amination. The DNA binding properties of these compounds have been examined and compared to those of reference drugs using an UV spectroscopy method. The compounds were evaluated for their in vitro anticancer activity and some of them were studied in vivo. Compound 15 exhibited remarkable antitumor activity and represents a novel template for anticancer chemotherapy and can serve as a new lead compound.
