PERSONAL DE APOYO
GULIN Julian Ernesto Nicolas
congresos y reuniones científicas
Título:
Evaluation of benznidazole metabolism in an in vitro system using pig liver microsomes
Autor/es:
ROCCO, DM; ARCE, LB; GULIN, JEN; MASTRANTONIO GARRIDO, GE; GARCÍA BOURNISSEN, F
Lugar:
Montevideo
Reunión:
Workshop; Workshop Drug Discovery for Neglected Diseases and Malaria; 2016
Institución organizadora:
Facultad de Química ? Universidad de la República.
Resumen:
Treatment of Chagas disease involves the administration either one of two antiparasitic drugs with proven efficacy: nifurtimox or benznidazole (BNZ). BNZ is the drug of choice in many Latin American countries due to availability issues, but there is few information about it metabolism .Understanding BNZ biotransformation is critical to understanding its side effects and predicting potential drug-drug and drug-disease interactions.This is an initial study in which we analyzed a possible pathway of BNZ metabolism using microsomes from pig liver in aerobic conditions in vitro.
