Hemoxygenase-1 involvement in breast cancer.

GANDINI, N.A.; COLÓ, G.P.; ALONSO, E.N.; FERMENTO, M.E.; MASCARÓ, M.; FERRONATO, M.J.; ABBA, M.C.; ARÉVALO, J.; IBARRA, A.; BARRERA LAMAS, N.; CURINO, A.C.; FACCHINETTI, M.M.

Bariloche

Simposio; IV South American Symposium in Signal Transduction and Molecular Medicine (SISTAM).; 2018

SISTAM

HO-1 is an enzyme involved in cellular responses to oxidative stress and has also been shown to regulate processes related to cancer progression. In this regard, HO-1 has been shown to display a dual effect with either antitumor or protumor activity,being this also true for breast cancer (BC). On the other hand, it has been reported that HO-1 can translocate to multiple subcellular compartments and can have nonenzymatic signaling roles. Thus, in the nucleus the protein may act as a transcriptional co-regulator protein and can bind and modulate other important proteins. In this work we intended to address this discrepancy regarding the role of HO-1 in BC. In vivo experiments showed that both pharmacological activation and genetic overexpression of HO-1 reduced the tumor burden in two different animal models of BC. Furthermore, the activation of HO-1 in several BC cell lines reduced cellular viability by inducing apoptosis (p