Heme Oxigenase-1 decreases the invasive phenotype in breast cancer.

CURINO, A.C.; FERRONATO, M.J.; ALONSO, E.N.; FERMENTO, M.E.; OBIOL, D.J.; FACCHINETTI, M.M.; GANDINI,N.A.

Bariloche

Simposio; III South American Symposium in Signal Transduction and Molecular Medicine (SISTAM).; 2015

SISTAM CONICET

Cell invasion involves changes in cell-cell and cell-extracellular matrix interactions. The E-cadherin (E-cadh) and β-catenin (β-cat) participate as anchor proteins of epithelial cell-cell and have been deregulated in breast cancer (BC). Previous results from our laboratory demonstrated the role of heme oxygenase 1 (HO-1) in the progression of BC. The aim of this work was to study the role of HO-1 in the modulation of these proteins and the regulation of cell migration and invasion. In human BC biopsies, we detected by immunohistochemistry (IHC), that there is a positive correlation between the expression of HO-1 and E-cadh (p = 0.0144; Spearman test). In the murine LM3 BC cells we observed by immunofluorescence and western blot (WB) increased expression of E-cadh and β-cat (p