Comparison study of plasma coenzyme Q10 and other antioxidants levels in healthy subjects supplemented with different coenzyme Q10 formulations

SAMASSA, P; MARTINEFSKI M; BUONTEMPO F; HOCHT C; LUCANGIOLI S.; TRIPODI V

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2016

Coenzyme Q10 (CoQ10) is a lipophilic molecule considered an antioxidant agent. CoQ10 deficiency is involved in mitochondrial, cardiological and degenerative muscle and neuronal disease. Most patients with these deficiencies have shown clinical improvement with oral CoQ10 supplementation, especially in infants. The aim of this work was to conduct a preliminary comparison of the plasma CoQ10 levels after a single dose and one week supplementation with two different CoQ10 formulation: commercial grade CoQ10 powder (solid formulation) and a new oil-in-water liquid emulsion. An additional objective was to evaluate the effect of 1-week CoQ10 supplementation at the levels of other antioxidants such as vitamins A, E and C.Six healthy individuals participated in a randomized, crossover, open, consecutive design, with a 2-week washout period. Pharmacokinetic parameters have been assessed after single and multiple intakes of 250 mg CoQ10 given daily for 1-week.The differences in the pharmacokinetic parameters of maximum plasma CoQ10 concentration, area under the curve between 0-360 and 0-4 h and elimination half-life were statistically significant (p