Urban air induces oxidative stress, inflammation and damage over time in mice olfactory bulb

FREIRE, AGUSTINA; GARCÉS, MARIANA; CÁCERES, LOURDES; REYNOSO, SOFÍA; MARCHINI, TIMOTEO; OCTAVIO, DAIANA; MARTINEFSKI, MANUELA R.; TRIPODI, VALERIA P.; ALVAREZ, SILVIA; CALABRÓ, VALERIA; MAGNANI, NATALIA; EVELSON, PABLO A.

Congreso; Reunión Anual de Sociedades de Biociencia 2022 - SAIC- SAI-SAFIS; 2022

Growing evidence support the notion that the central nervous system (CNS) is a highly relevant target of air particulate matter (PM). Oxidative stress and neuroinflammation are suggested to play a major role in the neurotoxicity after PM inhalation. In order to address such mechanisms, the aim of this work was to study the chronic effects of urban air on mice olfactory bulb (OB), focusing on oxidative stress and inflammation markers over time. Balb/C 8-week-old mice were exposed to filtered air (FA, control group) or urban air (UA) in whole body chambers for up to 4 weeks. Regarding OB redox status, UA exposed mice showed a decreased reduced glutathione level (GSH) (p