CHRONIC EXPOSURE TO URBAN AIR POLLUTION IN BUENOS AIRES CITY INDUCES OXIDATIVE STRESS AND INFLAMMATION IN MICE OLFACTORY BULB

FREIRE, AGUSTINA; GARCÉS, MARIANA; CÁCERES, LOURDES; MAGNANI, NATALIA; MARCHINI, TIMOTEO; MARTINEFSKI, MANUELA R.; TRIPODI, VALERIA P.; BERRA, ALEJANDRO; ALVAREZ, SILVIA; CALABRÓ, VALERIA; EVELSON, PABLO A.

Congreso; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2021

Previous reports indicate that central nervous system (CNS) is a target of air pollution, causing issue damage and functional alterations. Oxidative stress and neuroinflammation have been pointed out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice olfactory bulb (OB), focusing on oxidative stress and inflammation markers. Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body chambers, located in a highly polluted area of Buenos Aires city, for up to 4 weeks. Reduced glutathione levels (GSH) were decreased by 75% after 4 week of exposure to UA (p