PERSONAL DE APOYO
GAROFALO Ailin Natalia
artículos
Título:
The Length of the Staphylococcus aureus Protein A Polymorphic Region Regulates Inflammation: Impact on Acute and Chronic Infection
Autor/es:
GAROFALO AILIN; GIAI CONSTANZA; LATTAR SANTIAGO; GARDELLA NOELLA ; MOLLERACH MARTA; KAHL BARBARA ; BECKER KARSTEN; PRINCE ALICE S. ; SORDELLI DANIEL O.; GOMEZ MARISA
Revista:
JOURNAL OF INFECTIOUS DISEASES
Editorial:
UNIV CHICAGO PRESS
Referencias:
Lugar: Chicago; Año: 2012 p. 81 - 90
ISSN:
0022-1899
Resumen:
Staphylococcus aureus protein A (SpA) plays a critical role in the induction of inflammation. This study was aimed to determine whether the number of short sequence repeats (SSRs) present in the polymorphic region modulates the inflammatory response induced by SpA. We demonstrated that there is a dose-response effect in the activation of interferon (IFN)-beta signaling in airway epithelial and immune cells, depending on the number of SSRs, which leads to differences in neutrophil recruitment. We also determined that a significant proportion of isolates from patients with chronic infections such as osteomyelitis and cystic fibrosis carry fewer SSRs than do isolates from patients with acute infections or healthy carriers and that there was an inverse correlation between the number of SSRs and the length of disease course. Given the importance of IFN signaling in eradication of S. aureus, loss of SSRs may represent an advantageous mechanism to adapt to and persist in the host.
