PHARMACEUTICAL SEMISOLID FORMS CONTAINING Baccharis incarum EXTRACT

NUÑO G.; DANERT F. C.; ARIAS M.; ZAMPINI I.C.; ISLA M.I

Tafi del Valle, Tucumán

Jornada; XXV Jornadas Científicas de Biologia; 2008

Asociación de Biología de Tucumán

Baccharis incarum grows 3,800 meters above sea level (Antofagasta de la Sierra, Catamarca, Argentina). This species is commonly used as a gastric and hepatic protector, to reduce inflammatory processes, to treat sores, burns and leather wounds. In previous works we demonstrated its antimicrobial, free radical scavenging and antiinflammatory properties. The aim of this study was to design and develop pharmaceutical semisolid forms using B. incarum extract as a therapeutic agent. The extract was prepared from the aerial parts of B. incarum according to the Farmacopea Argentina VI Ed. Minimal Inhibitory Concentration (MIC) of the extract was determinated against multiresistant bacteria. Six creams were formulated: A) base, B) with gentamycin sulphate, C) with BHT, D) with gentamycin sulphate and BHT, E) with B incarum extract (4 x MIC values) and F) with B incarum extract (8 x MIC values). Stability and physical controls were carried out for 3 months. B. incarum formulations showed good stability. Its physical and organoleptic characteristics did not show changes and it was microbiologically stable at room temperature for 3 months. The formulation made from B. incarum extract fulfilled quality control. Ttherefore, it would be suitable for topical use in dermatological affections. Further studies of long-term stability and bioavailability will be carried out.