FORMULATION OF AN ANTIBIOTIC GEL WITH Acacia praecox EXTRACT FOR TOPICAL USE

DANERT F. C.; NUÑO G.; ARIAS M.; ZAMPINI I.C.; ISLA M.I

Tafi del Valle-Tucuman

Jornada; XXV Jornadas Científicas de Biologia; 2008

Asociación de Biología de Tucumán

Four species of the genus Acacia exist in northern and central Argentina: A. aroma, A.caven, A. Visco and A. praecox. They are traditionally used as antiseptics. In a previous work, we demonstrated that A.praecox showed antimicrobial activity against Gram-positive and Gram-negative bacteria. The aim of this study was to design and formulate pharmaceutical forms with antibiotic properties for topical use. Plant material was collected in Tapia, Tucumán, Argentina, in March 2007. Hydroalcoholic extract was prepared according to the Farmacopea Argentina VI Ed. Three formulations of hydrogel with Carbopol polymers were prepared: base hydrogel (G1), hydrogel with gentamycin sulphate (G2) and hydrogel with A. praecox extract (G3). Quality controls: physical and microbiological controls were performed during a three-month period. The results demonstrated that the formulation of A. praecox had good stability. Its physical and organoleptic characteristics did not show changes and it was microbiologically stable during the experience. The formulation made from A. praecox extract fulfilled quality control, so that it would be suitable for topical use in dermatological affections.