Factor de Crecimiento de Fibroblastos 21 Sérico (FGF21s) como biomarcador diagnóstico y pronóstico en pacientes con Carcinoma Celular Renal de Células Claras (CCRCC).

KNOT, ME; MINATTA, N; ROULTE, L; GUEGLIO G; PALLOTTA, MG; NUÑEZ, M; RANUNCOLO, SM; PURICELLI, LI; DE LORENZO, MS

CABA

Jornada; VI° Jornadas Integrales de Investigación y 13° Premio Prof. Dr. José Tessler.; 2016

Instituto de Investigación Básica y Medicina Experimental (ICBME), Instituto Universitario y Hospital Italiano de Buenos Aires (IUHIBA).

Background: The finding of new biomarkers is needed to have a better sub-classification of primary renal tumors (RCC) as well as more reliable predictors of outcome and therapy response. In this study, we evaluated the role of circulating FGF21, an endocrine factor, as a diagnostic and prognostic biomarker for ccRCC.Materials and Methods: Serum samples from healthy controls (HC), clear cell and chromophobe RCC cáncer patients were obtained from the serum biobank ?Biobanco Público de Muestras Séricas Oncológicas? (BPMSO) of the ?Instituto de Oncología ?Ángel H. Roffo?. Serum FGF21 and leptin were measured by ELISA while other metabolic markers were measured following routinely clinical procedures.Results: One of our major findings was that FGF21 levels were significantly increased in ccRCC patients compared with HC. Moreover, we showed an association between the increased serum FGF21 levels and the shorter disease free survival in a cohort of 98 ccRCC patients, after adjustment for other predictors of outcome.Conclusion: Our results suggest that higher FGF21 serum level is an independent prognostic biomarker, associated with worse free-disease survival.