The alternative NF-kB pathway interference induces a significant metabolic change in classical Hodgkin Lymphoma with potential therapeutic opportunities.

DÍAZ, MARIÁNGELES; LOMBARDO, TOMÁS; KORENBLIHTT, LAURA; BLANCO, GUILLERMO; RANUNCOLO, STELLA MARIS

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias. LXVIII Reunión Annual de la Sociedad Argentina de Investigación Clínica (SAIC). XXV Jornadas Anuales de la Sociedad Argentina de iología (SAB). LV Reunión Anual de la Asociación Argentina de Farmacología Experim; 2023

SAIC-SAB-AAFE-AACyTAL-

We previously shown the constitutive activation of the alternative NFkB arm (RelB/p52 mediated) role in classical Hodgkin Lymphoma (cHL) survival. It has been reported that the Hodgkin and Reed-Sternberg cells (malignant cHL cells) are OXPHOS (oxidative phosphorylation) dependent. We revisited our expression arrays (induced shRelB vs non-induced shRelB human UH01 cells) to evaluate RelB involvement in metabolism regulation. Differentially expressed genes (DEG) were explored with the limma R package, considering the top 10000 DEG with 5% FDR (adjusted p-value