INVESTIGADORES
ANGELINA Emilio Luis
congresos y reuniones científicas
Título:
An inverse docking approach with biological networks to understand the effect of C. citratus compounds on chagas disease
Autor/es:
GOMEZ CHAVEZ, JOSE LEONARDO; CONTI, GERMAN; PEREZ, RAFAEL ERNESTO; ANGELINA, EMILIO LUIS; PERUCHENA, NÉLIDA MARIA
Lugar:
Corrientes, Argentina
Reunión:
Congreso; XII CAB2C - 12vo Congreso Argentino de Bioinformática y Biología Computacional; 2022
Institución organizadora:
Asociación Argentina de Bioinformática y Biología Computacional - A2B2C
Resumen:
BACKGROUNDThe chronic stage of Chagas disease is characterized by intense cardiomyopathy caused by infection by the parasite Trypanosoma cruzi. Cymbopogon citratus extracts have been shown to be effective at this stage, relieving this pathology by reducing amastigote nets and inflammatory infiltrates in the cardiac tissue of mice.In this work, bioinformatic tools together with chemoinformatic and virtual screening tools were used to understand the mechanism of action at the molecular level of Cymbopogon citratus extract in chagasic cardiomyopathy.RESULTSThe functional enrichment study of the GSE41089 dataset consisting of gene expression data in the heart of mice infected with T. cruzi versus control, resulted in a set ofoverexpressed genes (logFold-Change>1 and adjusted p-value
