COULD SOY PROTEIN BE A PALLIATIVE ALTERNATIVE FOR THE CEREBELLUM UNDER CADMIUM CHRONIC INTOXICATION?

MARTIN MOLINERO GLENDA D; BOLDRINI GABRIEL GIEZI; PEREZ CHACA MARIA VERONICA; MOYANO MARIO FRANCO; ARMONELLI FIEDLER SAMANTA; GOMEZ NN; LOPEZ PHH; ALVAREZ SILVINA

Mar del Plata

Congreso; Reunión Anual de la Sociedad Argentina de Investigacion Clinica; 2022

SAIC

Cadmium (Cd) is an environmental contaminant. Our aim was tostudy its toxicity in cerebellum and the potential palliative effect ofa vegetarian diet. We determined Cd concentration in total bloodand cerebellar tissue by ICP-MS. Oxidative stress and apoptosismarkers were analyzed by PCR and immunohistochemistry. FemaleWistar rats (12 animals/group) were fed with casein (Cas) and soybean(So) as protein source for 60 days. Simultaneously, half of theanimals were administered either 15 ppm of Cd in water or wateras control ad libitum. Our results showed that Cd concentration intotal blood was incremented in CasCd vs. CasCo(p