EFFECT OF LOSARTAN PRETREATMENT ON KIDNEY LIPID CONTENT AFTER UNILATERAL OBSTRUCTION IN RATS

MANUCHA W; CARRIZO L; ALVAREZ SILVINA M; VALLES P; OLIVEROS L

CELLULAR AND MOLECULAR BIOLOGY

C M B ASSOC

Año: 2005 vol. 51 p. 539 - 545

0145-5680

Intrarenal concentration of angiotensin II increases after the onset of ureteral obstruction in the obstructed kidney. The effect of pretreatment with losartan, a specific angiotensin II AT1 receptor antagonist, on lipid contents, which were previously modified by unilateral ureteral obstruction (UUO), was studied in renal cortex of rats. Adult Wistar Kyoto rats were subjected to either UUO for 24 hr or control sham operation after being treated with losartan in the drinking water at 10 mg/kg rat/day for 15 days. In the cortex of obstructed kidney the increased free and esterified cholesterol concentrations were associated with the increased cholesterol synthesis measured by incorporation of 14C-acetate (p