Azole resistance in Neonatal Intensive Care Units

GIUSIANO G; MANGIATERRA M; ROJAS F; GÓMEZ V

Journal of Chemotheraphy

E.S.I.F.T. SRL

Año: 2005 vol. 17 p. 347 - 350

1973-9478

The aim of this study was to determine the antifungal susceptibility profile and to detect  resistant strains of yeast species isolated from neonates in Intensive Care Units. 92 strains isolated from 25 bloodstream cultures, 20 venous catheters, 23 suprapubic aspirations and 24 rectal swabs were studied. A Candida glabrata strain resistant to fluconazole was detected. Candida krusei appeared with its inherently resistance to fluconazole and showed cross-resistance to itraconazole. Two Candida albicans were resistant to azolic drugs, one to itraconazole and the other strain to fluconazole with a high MIC to itraconazole. All Candida tropicalis were susceptible to fluconazole but two of them showed resistance to itraconazole. Its noteworthy the detection of resistant strains in neonates whom has not received previous antifungal therapies. The variations in the epidemiology of fungal infections observed and the antifungal resistance detected, emphasize the importance of performing a permanent surveillance to observe and to assess them.